2-Pyrrolidone → 1-{3-Chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one

HRID 2411683Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411683
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([Cl:30])[CH:9]=1>>[Cl:30][C:10]1[CH:9]=[C:8]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=2)[CH2:20][CH2:21]1)=[O:15]

Komponenten

3

Edukt 2

HCID 120252-PyrrolidoneHCID 58484833(4-Bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 712519711-{3-Chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-oneAusbeute 66,3 %

Versuchsvorschrift

Using pyrrolidin-2-one (23 mg) and (4-bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (100 mg) described in Preparation Example 119 and by the reaction and treatment in the same manner as in Example 1, the title compound (67 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 119 and by the reaction and treatment in the same manner as in Example 1

Quellen und Nachweise

ORD-Eintrag
ord-071fe15e617d4a47bab7dec7b1ca6184
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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