4-((2-Oxopyrrolidin-1-yl)methyl)benzoic acid → HCID 71251923, Verbindung

HRID 2411728Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411728
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1>>[CH:17]1([C:20]2[CH:21]=[C:22]([CH3:32])[C:23]([N:26]3[CH2:27][CH2:28][N:29]([C:12]([C:11]4[CH:10]=[CH:9][C:8]([CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][C:2]5=[O:1])=[CH:16][CH:15]=4)=[O:14])[CH2:30][CH2:31]3)=[N:24][CH:25]=2)[CH2:19][CH2:18]1

Komponenten

3

Edukt 2

HCID 49622004-((2-Oxopyrrolidin-1-yl)methyl)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Produkt 1

HCID 71251923HCID 71251923, VerbindungAusbeute 36,1 %

Versuchsvorschrift

Using 4-(2-oxopyrrolidin-1-ylmethyl)benzoic acid (132 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (156 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (91 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87

Quellen und Nachweise

ORD-Eintrag
ord-c3b2397d86e049a7a308847c7023e841
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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