1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → (1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester

HRID 2411832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411832
[CH2:1]([O:3][C:4]([NH:6][C:7]([C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[O:5])[CH3:2].[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)CC1>>[CH2:1]([O:3][C:4](=[O:5])[NH:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:26]3[C:25]([CH3:35])=[CH:24][C:23]([CH3:20])=[CH:28][N:27]=3)[CH2:30][CH2:31]2)=[O:16])=[CH:18][CH:19]=1)([CH3:8])[CH3:9])[CH3:2]

Komponenten

3

Edukt 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252297Methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate

Produkt 1

HCID 71252363(1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl esterAusbeute 84,4 %

Versuchsvorschrift

Using methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate (174 mg) described in Preparation Example 70 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (157 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (235 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Quellen und Nachweise

ORD-Eintrag
ord-3dc63005760b4cde815bd02ad4a62f0d
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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