Hydrochloric Acid → Methyl 4-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)benzoate hydrochloride

HRID 241185Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 241185
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]3[O:20][CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][C:15]=3[CH:28]=2)=[CH:7][CH:6]=1)=[O:4].[ClH:29]>CO.O1CCOCC1>[ClH:29].[O:20]1[C:14]2[CH:13]=[CH:12][C:11]([C:8]3[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=3)=[CH:28][C:15]=2[CH2:16][NH:17][CH2:18][CH2:19]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 668201301,1-dimethylethyl 7-{4-[(methyloxy)carbonyl]phenyl}-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Produkt 1

HCID 66820482Methyl 4-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)benzoate hydrochlorideAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

To a solution of 1,1-dimethylethyl 7-{4-[(methyloxy)carbonyl]phenyl}-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (1.90 g, 4.96 mmol) in dry methanol (10 mL) was added drop wise 4 N hydrogen chloride in dioxane (10 mL) at room temperature. The reaction mixture was warmed to 55° C. for 60 min, at which time it was cooled to room temperature. The precipitated product was isolated by filtration, washed with diethyl ether, and dried to yield methyl 4-(2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)benzoate hydrochloride (1.53 g, 97% yield) as a white solid.

Aufarbeitung

  1. temperaturewas cooled to room temperature
  2. customThe precipitated product was isolated by filtration
  3. washwashed with diethyl ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b68d9a4735eb4a509e647b1068cf1cdf
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648066B2

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