(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → 3-Benzoyl-1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4,4-dimethylimidazolidin-2-one

HRID 2411864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411864
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:24])[CH:3]=1.[C:25]([N:33]1[C:37]([CH3:39])([CH3:38])[CH2:36][NH:35][C:34]1=[O:40])(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:25]([N:33]1[C:37]([CH3:38])([CH3:39])[CH2:36][N:35]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[C:4]([F:24])[CH:3]=2)[C:34]1=[O:40])(=[O:32])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Komponenten

3

Edukt 2

HCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712521131-Benzoyl-5,5-dimethylimidazolidin-2-one

Produkt 1

HCID 712518543-Benzoyl-1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4,4-dimethylimidazolidin-2-oneAusbeute 58 %

Versuchsvorschrift

Using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (157 mg) described in Preparation Example 114 and 1-benzoyl-5,5-dimethylimidazolidin-2-one (105 mg) described in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 511, the title compound (123 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 58 and by the reaction and treatment in the same manner as in Example 511

Quellen und Nachweise

ORD-Eintrag
ord-3a1da9d1d274468082b7b65de1cf7d63
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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