Methyl iodide → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-3,5-dimethylimidazolidine-2,4-dione

HRID 2411879Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411879
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[NH:25][C:24]4=[O:30])=[CH:19][C:18]=3[CH3:31])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:32]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[N:25]([CH3:32])[C:24]4=[O:30])=[CH:19][C:18]=3[CH3:31])=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 712519331-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-5-methylimidazolidine-2,4-dione

Produkt 1

HCID 712522021-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-3,5-dimethylimidazolidine-2,4-dione

Versuchsvorschrift

Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-5-methylimidazolidine-2,4-dione (50 mg) described in Example 525 and methyl iodide (10 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (9 mg) was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-e8ef532c1e6a440dab6dd1bf0dff4dbf
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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