Methyl iodide → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-3,5-dimethylimidazolidine-2,4-dione

HRID 2411881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411881
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[NH:25][C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:32]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[N:25]([CH3:32])[C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 712524521-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-5-methylimidazolidine-2,4-dione

Produkt 1

HCID 712520551-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-3,5-dimethylimidazolidine-2,4-dione

Versuchsvorschrift

Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-5-methylimidazolidine-2,4-dione (90 mg) described in Example 528 and methyl iodide (17 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (22 mg) was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-4456186a3c864062b92ace45c92ace3c
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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