3,5,5-Trimethylimidazolidine-2,4-dione → 3,5,5-Trimethyl-1-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}imidazolidine-2,4-dione

HRID 2411939Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411939
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][N:26]1[C:30](=[O:31])[C:29]([CH3:33])([CH3:32])[NH:28][C:27]1=[O:34]>>[CH3:25][N:26]1[C:30](=[O:31])[C:29]([CH3:33])([CH3:32])[N:28]([C:2]2[CH:3]=[CH:4][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:6][N:7]=2)[C:27]1=[O:34]

Komponenten

3

Edukt 2

HCID 2375603,5,5-Trimethylimidazolidine-2,4-dioneHCID 58484612(6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 712523863,5,5-Trimethyl-1-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}imidazolidine-2,4-dioneAusbeute 63,1 %

Versuchsvorschrift

Using (6-bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (156 mg) described in Preparation Example 205 and 3,5,5-trimethylimidazolidine-2,4-dione (63 mg) described in Preparation Example 218 and by the reaction and treatment in the same manner as in Example 536, the title compound (114 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 218 and by the reaction and treatment in the same manner as in Example 536

Quellen und Nachweise

ORD-Eintrag
ord-d55e89af8999476e9085e93cc0b392fd
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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