Methanol → Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

HRID 2412529Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2412529
[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](Cl)=[O:5].C(N(CC)CC)C.[CH3:16][OH:17]>>[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:17][CH3:16])=[O:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 8471TriethylamineHCID 613453-Chloro-2,2-dimethylpropanoyl chloride

Produkt 1

HCID 543185Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

Versuchsvorschrift

219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.).

Aufarbeitung

  1. temperaturea chilled (0°-5° C.)
  2. custommost of the methanol was evaporated under reduced pressure
  3. extractionextracted with ether
  4. dry with materialThe extract was dried (MgSO4)
  5. customthe solvent was evaporated
  6. distillationThe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-1f3bcff321814e5ab32196f36e7b65f5
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04493728

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