2-(Hydroxymethyl)benzo[b]thiophene → tert-Butyl ({6-[(benzo[b]thiophen-2-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}tert-butoxycarbonylamino)acetate

HRID 241256

Reaktionsgleichung

Reaktionsgleichung von HRID 241256
[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[N:10]=1)([CH3:4])([CH3:3])[CH3:2].S1C=CN=C1C1C=CC(CNS(C2C=NC=CC=2)(=O)=O)=CC=1.[S:56]1[C:60]([CH2:61]O)=[CH:59][C:58]2[CH:63]=[CH:64][CH:65]=[CH:66][C:57]1=2>>[C:1]([O:5][C:6](=[O:33])[CH2:7][N:8]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH2:61][C:60]2[S:56][C:57]3[CH:66]=[CH:65][CH:64]=[CH:63][C:58]=3[CH:59]=2)[NH:16][S:17]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)(=[O:18])=[O:19])[N:10]=1)[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 27763352-(Hydroxymethyl)benzo[b]thiopheneHCID 66717376N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamideHCID 86651773Tert-butyl (tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

Produkt 1

HCID 86651776tert-Butyl ({6-[(benzo[b]thiophen-2-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}tert-butoxycarbonylamino)acetateAusbeute 93,1 %

Versuchsvorschrift

Reaction and post-treatment were carried out in the same manner as in Example 2-(a) except for using tert-butyl(tert-butoxycarbonyl{6-[(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate (126 mg, 0.263 mmol) obtained in Reference Example 12-(d) in place of N-[4-(thiazol-2-yl)benzyl]pyridin-3-ylsulfonamide, and using benzo[b]thiophen-2-ylmethanol (43.2 mg, 0.263 mmol) in place of tert-butyl[tert-butoxycarbonyl(6-hydroxymethylpyridin-2-yl)amino]acetate to afford the title compound (153 mg) as a slightly yellow liquid. (Yield: 93%)

Aufarbeitung

  1. customReaction

Quellen und Nachweise

ORD-Eintrag
ord-ba2a301fb14d4020ab242f9cbd27fa85
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648097B2

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