4-(n-Hexadecanamido)-3-methylbenzoic acid → 2-(n-Pentadecyl)indole-5-carboxylic acid

HRID 2412591

Reaktionsgleichung

Reaktionsgleichung von HRID 2412591
[C:1]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][C:20]=1[CH3:28])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].CC(C)([O-])C.[K+]>>[CH2:2]([C:1]1[NH:18][C:19]2[C:20]([CH:28]=1)=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:26][CH:27]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

3

Edukt 2

HCID 128000094-(n-Hexadecanamido)-3-methylbenzoic acidHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 127972172-(n-Pentadecyl)indole-5-carboxylic acidAusbeute 59,9 %

Versuchsvorschrift

A mixture of 4-(n-hexadecanamido)-3-methylbenzoic acid (6.3 g) and potassium tert-butoxide (25 g) was treated in a similar manner to that described hereinbefore in Example 1 to give 2-(n-pentadecyl)indole-5-carboxylic acid (3.6 g), in the form of a white solid, m.p. 110°-112° C.

Aufarbeitung

  1. additionwas treated in a similar manner to that

Quellen und Nachweise

ORD-Eintrag
ord-d4cb807927ed4c99acdc46c2202aa557
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04493843

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