Sodium Hydroxide → 6-(11-Hydroxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol

HRID 2412838Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2412838
[OH-].[Na+].C([O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([C:19]1[C:24]([OH:25])=[C:23]([O:26][CH3:27])[C:22]([O:28][CH3:29])=[CH:21][C:20]=1[CH3:30])=[O:18])(=O)C>CO>[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([C:19]1[C:24]([OH:25])=[C:23]([O:26][CH3:27])[C:22]([O:28][CH3:29])=[CH:21][C:20]=1[CH3:30])=[O:18]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 204311686-(11-Acetoxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol

Produkt 1

HCID 132762366-(11-Hydroxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenolAusbeute 98,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium hydroxide (7 g) is added to a solution of 6-(11-acetoxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol (34 g) in methanol (300 ml) and the mixture is stirred at room temperature for 2 hours. To the reaction mixture is neutralized with 5N--HCl and the solvent is distilled off, whereupon crude crystals are obtained. These crystals are rinsed with water and recrystallized from ether-hexane (1:1). The above procedure yields colorless needles of 6-(11-hydroxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol (30 g), m.p. 81° C.

Aufarbeitung

  1. distillationHCl and the solvent is distilled off
  2. customwhereupon crude crystals are obtained
  3. washThese crystals are rinsed with water
  4. customrecrystallized from ether-hexane (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-2dd470078ead4e169b14a2cf64476560
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04495104

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