Hydrogen Bromide → HCID 54162042, Verbindung

Hydrogen bromide gas was added over a period of about 30 minutes to a solution of 2-fluorobutyrolactone (1.8 g) in ethanol (15 ml) at 0° C. The reaction mixture was left at room temperature for 3 days, after which it was evaporated in vacuo. The residue was dissolved in icewater, the solution was neutralized with sodiumcarbonate and extracted with ether. The ether solution was washed with an aqueous saturated Na2SO4 solution, dried over Na2SO4 and evaporated to give 4-bromo-2-fluorobutyric acid ethyl ester (1.26 g, 34%). nD20 =1.4698. 1H-NMR (CDCl3, MeSi)δ: 1.3 (t, J=7 Hz, CH3); 2.1-2.8 (m, CH2); 3.55 (t, J=7 Hz, CH2Br); 4.3 (q, J=7 Hz, CH2); 4.75 and 5.55 (two triplets, J=6 Hz, CHF, JCHF =50 Hz).

1. customafter which it was evaporated in vacuo
2. dissolutionThe residue was dissolved in icewater
3. extractionextracted with ether
4. washThe ether solution was washed with an aqueous saturated Na2SO4 solution
5. dry with materialdried over Na2SO4
6. customevaporated

ORD-Eintrag

ord-44ae91d2a4b34399aa27dd4ba5215963

Quelldatensatz

uspto-grants-1985_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04495190