Triethylamine → N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

HRID 24135

Reaktionsgleichung

Reaktionsgleichung von HRID 24135
[CH3:1][C:2]([CH3:7])=[CH:3][C:4](Cl)=[O:5].[Br:8][C:9]1[CH:16]=[CH:15][C:12]([NH:13][CH3:14])=[CH:11][CH:10]=1.C(N(CC)CC)C>ClCCl>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([N:13]([CH3:14])[C:4](=[O:5])[CH:3]=[C:2]([CH3:7])[CH3:1])=[CH:11][CH:10]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 2757052Benzenamine, 4-bromo-N-methyl-

Produkt 1

HCID 22568913N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3,3-Dimethylacryloyl chloride (3 mL, 27 mmol) was added to a solution of 4-bromo-N-methyl-aniline (4.55 g, 25 mmol) in 150 mL of dichloromethane followed after 5 minutes by triethyl amine (5 mL, 33 mmol). After 2.5 h at ambient temperature, the reaction mixture was washed with water and the organic phase was dried over anhydrous sodium sulfate and evaporated in vacuo to afford the title product as a brown oil in quantitative yield.

Aufarbeitung

  1. washthe reaction mixture was washed with water
  2. dry with materialthe organic phase was dried over anhydrous sodium sulfate
  3. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-90623539d9304fb8841d096e490d9518
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855512B2

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