Adenine → HCID 13536441, Verbindung

HRID 2413514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2413514
[S:1]1[CH:5]=[CH:4][C:3]([C:6](Cl)=[O:7])=[CH:2]1.[N:9]1[C:17]([NH2:18])=[C:16]2[C:12]([N:13]=[CH:14][NH:15]2)=[N:11][CH:10]=1>N1C=CC=CC=1>[CH:2]1[S:1][CH:5]=[CH:4][C:3]=1[C:6]([NH:18][C:17]1[N:9]=[CH:10][N:11]=[C:12]2[C:16]=1[NH:15][CH:14]=[N:13]2)=[O:7]

Komponenten

4

Edukt 2

HCID 190AdenineHCID 27763773-Thenoyl chloride

Produkt 1

HCID 13536441HCID 13536441, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

62.6 g (0.439 mole) of thiophene-3-carbonyl chloride are added to a suspension of 19.7 g (0.146 mole) of adenine in 100 ml of dry pyridine. The mixture is refluxed for 10 hours, the pyridine is distilled off, the residue is taken up in chloroform, the solution is washed with dilute sodium bicarbonate solution and dried over sodium sulfate, and the solvent is then stripped off in a rotary evaporator. The solid residue is stirred repeatedly with cyclohexane and then recrystallized from ethanol and dried at about 40° C. under reduced pressure. 6-(3-Thenoylamino)-purine is obtained in a yield of 60%.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 10 hours
  2. distillationthe pyridine is distilled off
  3. washthe solution is washed with dilute sodium bicarbonate solution
  4. dry with materialdried over sodium sulfate
  5. customthe solvent is then stripped off in a rotary evaporator
  6. customrecrystallized from ethanol
  7. customdried at about 40° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aec47a022e1740a7b713de7f63dd8bc5
Quelldatensatz
uspto-grants-1988_01
Patentnummer
US04718936

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