Hydrochloric Acid → HCID 13631101, Verbindung

In 28 ml of methanol was dissolved 1.44 g of ethyl α-(2-oxo-1-azetidinyl)acetate (19) and 10 ml of a 1N sodium hydroxide aqueous solution was dropwise added to the solution under ice cooling. The mixture was reacted at 10° to 15° C. for 1 hour. The reaction solution was ice-cooled and 10 ml of 1N-hydrochloric acid was added thereto. Methanol was removed by distillation under reduced pressure. After the remaining aqueous solution was saturated with sodium chloride, the mixture was extracted 3 times with 140 ml of ethyl acetate. The ethyl acetate extracts were combined and dried over anhydrous sodium sulfate and then concentrated to obtain 950 mg of α-(2-oxo-1-azetidinyl)acetic acid (20).

1. additionwas dropwise added to the solution under ice cooling
2. customThe mixture was reacted at 10° to 15° C. for 1 hour
3. temperaturecooled
4. customMethanol was removed by distillation under reduced pressure
5. extractionthe mixture was extracted 3 times with 140 ml of ethyl acetate
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated

ORD-Eintrag

ord-1a5cc4628cce4b1db21b8d41fddbde73

Quelldatensatz

uspto-grants-1988_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04719207