3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 4-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

HRID 2413860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2413860
[C:1]([C:5]1[CH:10]=[C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][C:6]=1[OH:17])([CH3:4])([CH3:3])[CH3:2].Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>N1C=CC=CC=1>[C:19]([O:17][C:6]1[CH:7]=[CH:8][C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:10][C:5]=1[C:1]([CH3:4])([CH3:2])[CH3:3])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

Komponenten

4

Edukt 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 97946452-t-butyl-4-cyclohexylphenol

Produkt 1

HCID 1985864-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

12 g (52 mmol) of 2-t-butyl-4-cyclohexylphenol and 10 g (56 mmol) of nicotinic acid chloride hydrochloride was mixed with 150 ml of dry pyridine and stirred for 48 hours at 35° C. After cooling precipitated pyridine hydrochloride was sucked off and the filtrate mixed with 75 ml of water. The precipitated raw product was freed from pyridine by washing with water and recrystallized from alcohol.

Aufarbeitung

  1. temperatureAfter cooling
  2. customprecipitated pyridine hydrochloride
  3. additionthe filtrate mixed with 75 ml of water
  4. customThe precipitated raw product
  5. washby washing with water
  6. customrecrystallized from alcohol

Quellen und Nachweise

ORD-Eintrag
ord-1f2647637d264ef593db1f20c295f294
Quelldatensatz
uspto-grants-1988_01
Patentnummer
USRE032581

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