Dimethylformamide dimethyl acetal → N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine

HRID 2414128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2414128
[Br:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[CH:4][CH:3]=1.CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>C(#N)C>[CH3:13][N:14]([CH3:16])[CH:15]=[N:10][S:7]([C:5]1[S:6][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:9])=[O:8]

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 12413045-Bromo-2-thiophenesulfonamide

Produkt 1

HCID 54319951N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

To a stirred mixture of 5-bromothiophene-2-sulfonamide (24.2 g, 0.10 mol) in acetonitrile (100 ml) was added dimethylformamide dimethyl acetal (14 ml) in acetonitrile (125 ml) dropwise over 0.5 hour. After an additional 0.5 hour the solvent was removed in vacuo. The residue was treated with water and the solid that precipitated was collected and dried, 28.7 g., m.p. 103°-105° C. Recrystallization from 1-chlorobutane gave material with m.p. 104°-106° C.

Aufarbeitung

  1. customAfter an additional 0.5 hour the solvent was removed in vacuo
  2. additionThe residue was treated with water
  3. customthe solid that precipitated
  4. customwas collected
  5. customdried
  6. customRecrystallization from 1-chlorobutane
  7. customgave material with m.p. 104°-106° C.

Quellen und Nachweise

ORD-Eintrag
ord-b5ae77c898774c65b6c661607a2c8528
Quelldatensatz
uspto-grants-1988_01
Patentnummer
US04721794

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