Sodium Azide → (2-Azido-ethoxy)methyl-phosphonic acid-diethylester

HRID 2414236Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2414236
[CH2:1]([O:3][P:4]([CH2:9][O:10][CH2:11][CH2:12]Cl)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[N-:14]=[N+:15]=[N-:16].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH2:1]([O:3][P:4]([CH2:9][O:10][CH2:11][CH2:12][N:14]=[N+:15]=[N-:16])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

Komponenten

5

Edukt 2

HCID 33557Sodium AzideHCID 10014096Diethyl ((2-chloroethoxy)methyl)phosphonate

Produkt 1

HCID 10037145(2-Azido-ethoxy)methyl-phosphonic acid-diethylester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

0,02 mol (2-chloroethoxy)methyl-phosphonic acid diethylester, 3 mmol tetrabutylammoniumbromide and 2,5 g sodiumazide are boiled in 50 ml toluol under reflux for 4 h. After cooling-off it is washed for three times with 25 ml water respectively. The watery phase may be extracted with toluol. The combined toluol phases are dried over sodiumsulfate and the solvent is removed in the vacuum. A yellow oil remains.

Aufarbeitung

  1. temperatureunder reflux for 4 h
  2. washAfter cooling-off it is washed for three times with 25 ml water respectively
  3. extractionThe watery phase may be extracted with toluol
  4. dry with materialThe combined toluol phases are dried over sodiumsulfate
  5. customthe solvent is removed in the vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1cc503066660426d933cb30d1cdcce9e
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06812224B2

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