6-chloro-N-isopropylnicotinamide → 5-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

HRID 2414330Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2414330
[ClH:1].[CH3:2][CH:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5](=[O:19])[O:4]1.Cl[C:21]1[N:26]=[CH:25][C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:22]=1>>[Cl:1][C:22]1[CH:23]=[C:24]([C:27]([NH:29][CH:30]([CH3:32])[CH3:31])=[O:28])[CH:25]=[N:26][C:21]=1[N:16]1[CH2:17][CH2:18][CH:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[CH:3]([CH3:2])[O:4][C:5]2=[O:19])[CH2:14][CH2:15]1

Komponenten

3

Edukt 2

HCID 8193696-chloro-N-isopropylnicotinamideHCID 226446811-(4-Piperidyl)-4-methyl-3,1-benzoxazin-2-one hydrochloride

Produkt 1

HCID 226446375-Chloro-n-(1-methylethyl)-6-[4-(4-methyl-2-oxo-2h-3,1-benzoxazin-1(4h)-yl)piperidin-1-yl]pyridine-3-carboxamide

Versuchsvorschrift

The title compound was prepared from the product of step (ii) (0.36 g) and the product from example 117 step (i) (0.466 g) using the method of example 115 step (ii). Yield 0.112 g

Quellen und Nachweise

ORD-Eintrag
ord-372703aa2407456fb403edf33930f71c
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06812226B2

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