Hydrochloric Acid → HCID 22643446, Verbindung
Reaktionsgleichung
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>CO>[ClH:32].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([O:19][CH:20]4[CH2:24][CH2:23][NH:22][CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of thus-obtained t-butyl 3-{[1-(phenylsulfonyl)-1H-indol-4-yl]oxy}-1-pyrrolidinecarboxylate (0.41 g, 0.93 mmol) in methanol and HCl (5.0 ml, 1M in ether) is heated at 60° C. under nitrogen for 2 h and concentrated in vacuo. The residue is treated with ethyl acetate and filtered. The filtercake is dried under vacuum to give the title product as an off white solid, 0.301 g, mp 200-201° C., identified by NMR and mass spectral analyses.