1-(6-Methylpyridin-2-yl)piperazine → 9-{4-[4-(6-methyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide
Reaktionsgleichung
[CH3:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[F:14][C:15]1[CH:42]=[CH:41][C:18]([CH2:19][NH:20][C:21]([C:23]2([CH2:36][CH2:37][CH2:38][CH2:39]Br)[C:35]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:29]3[C:24]2=[CH:25][CH:26]=[CH:27][CH:28]=3)=[O:22])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][NH:20][C:21]([C:23]2([CH2:36][CH2:37][CH2:38][CH2:39][N:11]3[CH2:12][CH2:13][N:8]([C:6]4[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=4)[CH2:9][CH2:10]3)[C:35]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:29]3[C:24]2=[CH:25][CH:26]=[CH:27][CH:28]=3)=[O:22])=[CH:41][CH:42]=1Komponenten
3
Versuchsvorschrift
Prepared analogously to Example 2 b from 1-(6-methyl-pyridin-2-yl)-piperazine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluorobenzyl-amide.
Quellen und Nachweise
- ORD-Eintrag
- ord-c3e0b92cb9ca4ce1a2e946bf5c43824c
- Quelldatensatz
- uspto-grants-2004_11