Trifluoroacetic acid → 1-(6-Phenyl-pyridin-2-yl)-piperazine

HRID 2415168Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2415168
[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68577637Tert-butyl 4-(6-phenylpyridin-2-yl)piperazine-1-carboxylate

Produkt 1

HCID 226401851-(6-Phenyl-pyridin-2-yl)-piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 0.7 g (2.06 mmol) of tert.butyl 4-(6-phenyl-pyridin-2-yl)-piperazine-1-carboxylate and 3 ml of trifluoroacetic acid in 30 ml of dichloromethane is stirred for three hours at ambient temperature. The solvent is then distilled off, the residue is combined with water and made basic with sodium hydroxide solution. It is then extracted with dichloromethane and the organic phase is separated off and dried over sodium sulphate.

Aufarbeitung

  1. distillationThe solvent is then distilled off
  2. extractionIt is then extracted with dichloromethane
  3. customthe organic phase is separated off
  4. dry with materialdried over sodium sulphate

Quellen und Nachweise

ORD-Eintrag
ord-bc06fdb1fa914bbab7af4e3ad94e33e1
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06818644B1

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