N-(2-bromo-phenyl)-3-ethoxy-acrylamide → 8-Bromo-1,2-dihydroquinolin-2-one

HRID 2415890

Reaktionsgleichung

Reaktionsgleichung von HRID 2415890
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]OCC>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9](=[O:15])[CH:10]=[CH:11]2

Komponenten

3

Edukt 1

HCID 68586854N-(2-bromo-phenyl)-3-ethoxy-acrylamide

Produkt 1

HCID 109330948-Bromo-1,2-dihydroquinolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

6 g (22.21 mmol) of N-(2-bromo-phenyl)-3-ethoxy-acrylamide are added batchwise to 30 ml of concentrated sulphuric acid (exothermic) and stirred for one hour. The reaction mixture is poured onto ice water and the precipitate formed is filtered off. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1).

Aufarbeitung

  1. additionThe reaction mixture is poured onto ice water
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1)

Quellen und Nachweise

ORD-Eintrag
ord-42055ce2719743f388da10fbe354df72
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06821967B2

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