HCID 22638572, Verbindung → HCID 10151373, Verbindung

HRID 2416215Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2416215
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3N=C(CSC4C=CC=CC=4)S[CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.[NH2:27][C:28](=[S:41])[C:29]([CH3:40])([CH3:39])[S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31]>CO>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:14]3[N:27]=[C:28]([C:29]([CH3:39])([S:30]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)(=[O:32])=[O:31])[CH3:40])[S:41][CH:18]=3)[C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 22638572HCID 22638572, VerbindungHCID 22638635HCID 22638635, Verbindung

Produkt 1

HCID 10151373HCID 10151373, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

This compound was prepared according to the procedure described for Example 8836(c) by employing 3-(2-bromo-acetyl)-7-methoxy-1H-quinolin-2-one (Example 8741, 250 mg, 0.84 mmol) and 2-amino-1,1-dimethyl-1-(phenylsulfonyl)ethane-2-thione (Step b, 1.7 mL, 1.0 mmol) in 3.5 mL of anhydrous MeOH was heated at 120° C. for 3×5 min by microwave synthesizer. The reaction mixture was cooled to RT. The precipitates were collected by filtration and washed with MeOH and CH2Cl2 to provide the title compound as a white solid. MS m/z: 441 (M+1).

Aufarbeitung

  1. customThis compound was prepared
  2. temperatureThe reaction mixture was cooled to RT
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with MeOH and CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-0fb304276301458eabbdb4bb53227deb
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06822097B1

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