Hydrochloric Acid → HCID 22633074, Verbindung

HRID 2416652

Reaktionsgleichung

Reaktionsgleichung von HRID 2416652
[F:1][C:2]([F:19])([F:18])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1.[ClH:20]>C(OCC)(=O)C.CO>[ClH:20].[ClH:20].[F:19][C:2]([F:1])([F:18])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 22633053tert-Butyl 4-(3,3,3-trifluoropropyl)-1-piperazine-carboxylate

Produkt 1

HCID 22633074HCID 22633074, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel3×

Versuchsvorschrift

To a solution of tert-butyl 4-(3,3,3-trifluoropropyl)-1-piperazinecarboxylate (5.77 g) in ethyl acetate (13 ml) and methanol (10 ml) was added dropwise 4N hydrogen chloride in ethyl acetate (29 ml) at 0° C. The mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was diluted with ethyl acetate. The resulting precipitate was collected by filtration, washed with ethyl acetate and dried in vacuo to give the title compound (4.70 g) as a pale yellow solid.

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2433db7004dd4e0fa52156fbfdc13bee
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06825200B1

Verknüpfte Notizen

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