p-Chlorophenacyl bromide → 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

HRID 241735

Reaktionsgleichung

Reaktionsgleichung von HRID 241735
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=O.C([O:14][C:15]([NH:17][NH2:18])=[S:16])C>C(#N)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[CH2:2][S:16][C:15](=[O:14])[NH:17][N:18]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 68303p-Chlorophenacyl bromideHCID 12567113O-Ethyl hydrazinecarbothioate

Produkt 1

HCID 3294735-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (90.71 mmoles) and hydrazine-carbothioic acid O-ethyl ester (90.71 mmoles) in acetonitrile (84 ml) is stirred at ambient temperature for 3 hours. The solid formed is filtered off, washed with acetonitrile and ethyl ether and then dried in vacuo to yield the title product, which is used directly in the next Step.

Aufarbeitung

  1. customThe solid formed
  2. filtrationis filtered off
  3. washwashed with acetonitrile and ethyl ether
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ac965aab873d4f019cf92ec011495b64
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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