p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one

HRID 241738

Reaktionsgleichung

Reaktionsgleichung von HRID 241738
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 68303p-Chlorophenacyl bromideHCID 2735122Potassium Formate

Produkt 1

HCID 5870851-(4-Chlorophenyl)-2-hydroxyethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.

Aufarbeitung

  1. temperatureat reflux for 3 hours
  2. additionThe reaction mixture is poured
  3. customonto crushed ice
  4. customThe solid formed
  5. filtrationis filtered off
  6. washwashed with cold MeOH
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6f0e5a2260e14700985cfcc1f1b5068d
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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