1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-nitroanilino)-piperidine → 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-aminoanilino)-piperidine

HRID 2417803Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2417803
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[N+:26]([O-])=O)[CH2:14][CH2:13]1.[H][H]>[Ni].C(O)C>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[NH2:26])[CH2:14][CH2:13]1

Komponenten

5

Edukt 2

HCID 204467111-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-nitroanilino)-piperidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 204467041-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-aminoanilino)-piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

20 g of 1-[(benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chloro-2-nitroanilino)-piperidine were hydrogenated under normal pressure and at room temperature, using 4 g of Raney nickel as a catalyst in 200 ml of ethanol. When the uptake of hydrogen had ended, the mixture was filtered, the material on the filter was rinsed with ethanol and the filtrate was concentrated.

Aufarbeitung

  1. customwere hydrogenated under normal pressure and at room temperature
  2. filtrationthe mixture was filtered
  3. washthe material on the filter was rinsed with ethanol
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-684dece3bc2445b8890d86e1f3f22fce
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04470989

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