Clonazepam → ID 690

HRID 2418318

Reaktionsgleichung

Reaktionsgleichung von HRID 2418318
[C:1](=[O:4])([O-])[O-].[K+].[K+].CI.[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[C:22]2[CH:23]=[C:24]([N+:27]([O-:29])=[O:28])[CH:25]=[CH:26][C:21]=2[NH:20][C:19](=O)[CH2:18][N:17]=1>CC(C)=O>[Cl:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[C:22]2[CH:23]=[C:24]([N+:27]([O-:29])=[O:28])[CH:25]=[CH:26][C:21]=2[N:20]([CH3:19])[C:1](=[O:4])[CH2:18][N:17]=1

Komponenten

5

Edukt 3

HCID 2802ClonazepamHCID 6328Methyl iodideHCID 11430Potassium Carbonate

Produkt 1

HCID 528222ID 690

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

42.4 g of potassium carbonate and 18.5 ml of methyl iodide are added to a solution of 50 g (0.158 mol) of 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one in 600 ml of acetone and the mixture is stirred at room temperature for 16 hours. After filtering-off insoluble material, the filtrate is evaporated and the residue is taken up in methylene chloride. The organic phase is washed once with water, dried and evaporated, there being obtained 5-(o-chlorophenyl)-1,3-dihydro-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one of melting point 220°.

Aufarbeitung

  1. customAfter filtering-off insoluble material, the filtrate is evaporated
  2. washThe organic phase is washed once with water
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-061f07e32c8342129964fa59931a8352
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04472435

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