Aniline → Butanamide, 4-chloro-3-oxo-N-phenyl-

HRID 2418483Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2418483
Cl[C:2]1([CH2:7][Cl:8])[O:5][C:4](=[O:6])[CH2:3]1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[Cl:8][CH2:7][C:2](=[O:5])[CH2:3][C:4]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:6]

Komponenten

5

Edukt 2

HCID 6115AnilineHCID 137182814-Chloro-4-(chloromethyl)oxetan-2-one

Produkt 1

HCID 38215Butanamide, 4-chloro-3-oxo-N-phenyl-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

7.8 Parts of 4-chloro-4-chloromethyloxetan-2-one are dissolved in 150 parts of methylenechloride containing 4.2 parts of anhydrous sodium bicarbonate and the solution is cooled to 0° C. 4.7 Parts of aniline are then added over 30 minutes and the reaction mixture is finally stirred for 48 hours at room temperature. The solids are then filtered off and the filtrate evaporated. The residue is crystallised twice from chloroform to give γ-chloroacetoacetanilide, m.p. 142°-143° C.

Aufarbeitung

  1. filtrationThe solids are then filtered off
  2. customthe filtrate evaporated
  3. customThe residue is crystallised twice from chloroform

Quellen und Nachweise

ORD-Eintrag
ord-c87d1c74da7b487382e536c1f2e9ad1f
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04472589

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