HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → HDTrp-Leu-MetNH2 trifluoroacetate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | BocDTrp-Leu-MetNH2 | HCID 131713756 | — |
| Lösungsmittel | Ethyl methyl sulfide | HCID 12230 | — |
| Lösungsmittel | 1,1-Ethanedithiol | HCID 33645 | — |
| Produkt | HDTrp-Leu-MetNH2 trifluoroacetate | HCID 131713755 | 23% |
Reaktionsschritte
Condensation of BocDTrpOPFP (8.60 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 5.44 g.) by the activated ester method gave BocDTrp-Leu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MetNH2 (6.69 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HDTrp-Leu-MetNH2 trifluoroacetate salt in 23% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04472305 |
| Quelldatensatz | uspto-grants-1984_09 |
| ORD ID | ord-61fdc32b2888445d9cfb55f8896090df |
| Quellennotiz | uspto-grants-1984_09 |