Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
Reaktionsgleichung
Cl[CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1.[NH3:11]>C(OCC)(=O)C>[NH2:11][CH2:2][C:3]1[NH:8][C:7](=[O:9])[NH:6][C:5](=[O:10])[CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, separated by filtration, and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
Aufarbeitung
- customto react overnight in a sealed bomb at about 20° C
- customseparated by filtration
- washwashed sequentially with water and methanol
Quellen und Nachweise
- ORD-Eintrag
- ord-579362fbdc4e4dc2bed4bbb1e3dcd3be
- Quelldatensatz
- uspto-grants-1984_09
- Patentnummer
- US04473570
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