Hydrochloric Acid → 4-Chloro-2-(3-trifluoromethyl-phenoxy)-benzyl alcohol

HRID 2419299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2419299
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=1.[BH4-].[Li+].Cl>O1CCCC1>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][OH:2])=[C:5]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=2)[CH:6]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 4148881Lithium borohydrideHCID 540086294-Chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester

Produkt 1

HCID 544081134-Chloro-2-(3-trifluoromethyl-phenoxy)-benzyl alcohol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of 103 g. of 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid methyl ester in 400 ml. of tetrahydrofuran is added dropwise at reflux over a period of 30 minutes to a solution of 16.2 g. of lithium borohydride in 280 ml. of absolute tetrahydrofuran. The mixture is then cooled to 0° C. and slowly added dropwise to 400 ml. of 3-N aqueous hydrochloric acid. After the addition of 500 ml. of water, the mixture is extracted twice with ether. After evaporation of the ether, there is obtained 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzyl alcohol in the form of an oil.

Aufarbeitung

  1. temperatureat reflux over a period of 30 minutes to a solution of 16.2 g
  2. additionslowly added dropwise to 400 ml
  3. additionAfter the addition of 500 ml
  4. extractionof water, the mixture is extracted twice with ether
  5. customAfter evaporation of the ether

Quellen und Nachweise

ORD-Eintrag
ord-a474ca1400e34e0b8a33889161b3c391
Quelldatensatz
uspto-grants-1978_08
Patentnummer
US04105664

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