Methanol → Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride

HRID 2419364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2419364
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][C:8]([C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:9].[CH3:21]O>>[ClH:3].[NH2:6][CH2:7][C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][C:16]([O:18][CH3:21])=[O:17])=[CH:19][CH:20]=1)=[O:9]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 145369464-(Aminoacetyl)phenoxyacetic acid hydrochloride

Produkt 1

HCID 20315552Methyl 4-(aminoacetyl)phenoxyacetate hydrochlorideAusbeute 62 %

Versuchsvorschrift

Methanol (250ml.) was stirred at -20° C. as thionyl chloride (6ml.) was added. 4-(Aminoacetyl)phenoxyacetic acid hydrochloride (5.0g) was added, and the mixture was stirred and allowed to warm to room temperature during 18 hours. The resulting solution was evaporated under reduced pressure and the residue was recrystallised from a mixture of methanol and diethyl ether to give methyl 4-(aminoacetyl)-phenoxyacetate hydrochloride, m.p. 202°-204° C. (Example 12) in 62% yield.

Aufarbeitung

  1. additionwas added
  2. customThe resulting solution was evaporated under reduced pressure
  3. customthe residue was recrystallised from a mixture of methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-800387dbdf12442491dfbf59280641f7
Quelldatensatz
uspto-grants-1978_08
Patentnummer
US04105790

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