2-(2-Chlorophenyl)-4-(diisopropylamino)butanenitrile → alpha-(o-Chlorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)acetonitrile
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:9]#[N:10].FC1C=CC=CC=1[CH:27]([CH2:30][CH2:31][N:32]([CH:36]([CH3:38])C)[CH:33]([CH3:35])C)C#N>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:15])[CH3:16])([CH2:38][CH2:36][N:32]1[CH2:31][CH2:30][CH2:27][CH2:35][CH2:33]1)[C:9]#[N:10]Komponenten
3
Versuchsvorschrift
When an equivalent quantity of α-(o-chlorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile prepared according to the first paragraph of Example 19, is substituted for α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile called for in Example 20 and the procedure detailed in the second paragraph of that example is substantially repeated, there is obtained α-(o-chlorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile, as an oil boiling at about 190°-195° C. at 0.3 mm. pressure.