Cyclopropanecarbonyl chloride → HCID 20314164, Verbindung
Reaktionsgleichung
[F:1][C:2]([F:21])([F:20])[C:3]([C:16]([F:19])([F:18])[F:17])([C:5]1[CH:6]=[CH:7][C:8]2[NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:15]=1)[OH:4].[CH:22]1([C:25](Cl)=[O:26])[CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[CH:22]1([C:25]([N:14]2[C:8]3[CH:7]=[CH:6][C:5]([C:3]([C:2]([F:1])([F:20])[F:21])([C:16]([F:19])([F:17])[F:18])[OH:4])=[CH:15][C:9]=3[CH2:10][CH2:11][CH2:12][CH2:13]2)=[O:26])[CH2:24][CH2:23]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 200 ml dry toluene is added 6.3 g (0.020 mole) α,α-bis(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-7-methanol and 3.0 g (0.025 mole) cyclopropane carboxylic acid chloride. The solution is stirred and heated at reflux under nitrogen for sixteen hours, then cooled and evaporated at reduced pressure. The residual solid is recrystallized from chlorobutane to give 5.0 g, m.p. 165°-167°.