2-Aminothiazole → HCID 178522565, Verbindung
Reaktionsgleichung
[OH:1][C:2]1[C:11]([C:12](OCC)=[O:13])=[C:10]([OH:17])[C:9]2[C:4](=[C:5]([C:18]([F:21])([F:20])[F:19])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:22][C:23]1[S:24][CH:25]=[CH:26][N:27]=1>C1(C)C(C)=CC=CC=1>[S:24]1[CH:25]=[CH:26][N:27]=[C:23]1[NH:22][C:12]([C:11]1[C:2]([OH:1])=[N:3][C:4]2[C:9]([C:10]=1[OH:17])=[CH:8][CH:7]=[CH:6][C:5]=2[C:18]([F:21])([F:20])[F:19])=[O:13]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 6.02 g of the product of Step C, 200 ml of xylene, 2 g of 2-amino-thiazole and 20 g of siliporite NK20 was refluxed for 2 hours and the resulting product was crystallized from acetic acid to obtain 5.54 g of N-(2-thiazolyl)-2,4-dihydroxy-8-trifluoromethyl-quinoline-3-carboxamide in the form of colorless crystals melting at 260° C.