Hydrochloric Acid → 1-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]methanamine

HRID 2420122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2420122
[Br-].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[C:12]([CH2:14][N+:15]34CN5CN(CN(C5)C3)C4)[O:11][N:10]=2)=[CH:5][CH:4]=1.Cl>CO>[NH2:15][CH2:14][C:12]1[O:11][N:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=2)[CH:13]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 20339738HCID 20339738, Verbindung

Produkt 1

HCID 27641631-[3-(4-Chlorophenyl)-1,2-oxazol-5-yl]methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 205 g. portion of the product of Example 5 was dissolved in 1.5 l. of methanol and 250 ml. of concentrated hydrochloric acid was added. The mixture was stirred at reflux temperature overnight, and the solvent was then evaporated under vacuum. The residue was neutralized with aqueous sodium hydroxide and the product was extracted from the aqueous mixture with methylene dichloride and was purified by evaporating the solvent and recrystallizing the residue from ethanol-petroleum ether. The product was 78 g. of 5-aminomethyl-3-(4-chlorophenyl)isoxazole, m.p. 81°.

Aufarbeitung

  1. temperatureat reflux temperature overnight
  2. customthe solvent was then evaporated under vacuum
  3. extractionthe product was extracted from the aqueous mixture with methylene dichloride
  4. customwas purified
  5. customby evaporating the solvent
  6. customrecrystallizing the residue from ethanol-petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-bc52914786b947368ba3dfea748f34e5
Quelldatensatz
uspto-grants-1978_08
Patentnummer
US04109002

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