Hydrochloric Acid → Indeloxazine Hydrochloride

HRID 2420182Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2420182
[ClH:1].C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:9]2[CH2:14][CH2:13][O:12][CH:11]([CH:15]([O:17][C:18]3[CH:26]=[CH:25][CH:24]=[C:23]4[C:19]=3[CH2:20][CH2:21][CH2:22]4)O)[CH2:10]2)C=CC=CC=1>C(O)C>[ClH:1].[CH2:20]1[C:19]2[C:23](=[CH:24][CH:25]=[CH:26][C:18]=2[O:17][CH2:15][CH:11]2[O:12][CH2:13][CH2:14][NH:9][CH2:10]2)[CH:22]=[CH:21]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 20313214HCID 20313214, Verbindung

Produkt 1

HCID 47517Indeloxazine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In 500 ml. of ethanolic hydrochloric acid (350 ml. of 0.5 N hydrochloric acid and 150 ml. of ethanol) was dissolved 5.0 g. of 4-triphenylmethyl-2-(1-hydroxy-4-indanyloxymethyl)-morpholine and the solution was refluxed 17 hours. After cooling the reaction mixture, ethanol was distilled away under reduced pressure until the whole volume of the reaction mixture became about 350 ml. Sodium chloride was added to the reaction mixture to cause salting out and the mixture was extracted three times each time with 200 ml. of chloroform. The chloroform extracts were combined, dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure. Then, by adding acetone to the syrupy residue formed, 2.0 g. of 2-(7-indenyloxymethyl)morpholine hydrochloride was obtained as a precipitate.

Aufarbeitung

  1. distillationwas distilled away under reduced pressure until the whole volume of the reaction mixture
  2. additionSodium chloride was added to the reaction mixture
  3. extractionwas extracted three times each time with 200 ml
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled away under reduced pressure
  6. additionThen, by adding acetone to the syrupy residue
  7. customformed

Quellen und Nachweise

ORD-Eintrag
ord-37463e11daf2448fa551417aa6193d90
Quelldatensatz
uspto-grants-1978_08
Patentnummer
US04109088

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