Ethanolamine → 6-(2-Hydroxyethylamino)nicotinaldehyde
Reaktionsgleichung
[NH2:1][CH2:2][CH2:3][OH:4].Cl[C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][N:7]=1>>[OH:4][CH2:3][CH2:2][NH:1][C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[O:11])=[CH:8][N:7]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 135 °C
Versuchsvorschrift
10.12 g (165.68 mmol) of 2-aminoethanol are added to 1.00 g (7.06 mmol) of 6-chloronicotinaldehyde, and the reaction mixture is then stirred at 135° C. for 14 h. This gives a yellow solution which is fractionated by distillation in a kugelrohr apparatus (2.2 mbar, 100° C.). The fraction comprising the desired product is then directly reacted further.
Aufarbeitung
- customThis gives a yellow solution which
- distillationis fractionated by distillation in a kugelrohr apparatus (2.2 mbar, 100° C.)
- customis then directly reacted further
Quellen und Nachweise
- ORD-Eintrag
- ord-e17903c7cbdb474ea0511ea1ea6cc076
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08653109B2
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