Thionyl Chloride → 4-(Chloromethyl)-N-(4-fluorophenyl)-6-methylpyrimidine-2-amine
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([CH2:15]O)[CH:12]=[C:11]([CH3:17])[N:10]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>ClCCl>[Cl:20][CH2:15][C:13]1[CH:12]=[C:11]([CH3:17])[N:10]=[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[N:14]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
At 0° C., 225 mg (0.96 mmol) of the compound from example 6A and 137 mg (1.16 mmol) of thionyl chloride are initially charged in 10 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
Aufarbeitung
- customThe solvent is removed on a rotary evaporator
- customthe product that remains is directly reacted further
Quellen und Nachweise
- ORD-Eintrag
- ord-4600fafe061d4f6399db50d26ec7e638
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08653109B2
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