Thionyl Chloride → 3-Chloro-6-(chloromethyl)pyridazine
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[N:6][C:5]([CH2:8]O)=[CH:4][CH:3]=1.S(Cl)([Cl:12])=O>ClCCl>[Cl:1][C:2]1[N:7]=[N:6][C:5]([CH2:8][Cl:12])=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
At 0° C., 200 mg (1.38 mmol) of the compound from example 10A and 198 mg (1.66 mmol) of thionyl chloride are initially charged in 1.5 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
Aufarbeitung
- customThe solvent is removed on a rotary evaporator
- customthe product that remains is directly reacted further
Quellen und Nachweise
- ORD-Eintrag
- ord-8b35af9988984d4588c8e0fda87ab1d5
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08653109B2
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