7-Chloro-4-hydrazinylquinoline → N'-(7-chloroquinolin-4-yl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotino-hydrazide
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[Cl:19][C:20]1[CH:29]=[C:28]2[C:23]([C:24]([NH:30][NH2:31])=[CH:25][CH:26]=[N:27]2)=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:29]=[C:28]2[C:23]([C:24]([NH:30][NH:31][C:12](=[O:14])[C:11]3[CH:15]=[CH:16][N:17]=[CH:18][C:10]=3[NH:9][C:3]3[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=3[F:1])=[CH:25][CH:26]=[N:27]2)=[CH:22][CH:21]=1Komponenten
3
Versuchsvorschrift
N′-(7-chloroquinolin-4-yl)-3-[(2-fluoro-4-iodophenyl)amino]isonicotino-hydrazide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.33 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.50 mmol of 7-chloroquinolin-4-yl-hydrazine.LC/MS [7.69 min; 534 (M+1)]
Aufarbeitung
- customLC/MS [7.69 min; 534 (M+1)]