Ethanol → N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromide

HRID 2422251Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2422251
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=O.[CH2:15]([NH:18][C:19]([NH2:21])=[S:20])[CH2:16][CH3:17].C(O)C>C(OC(C)C)(C)C>[BrH:1].[CH2:15]([NH:18][C:19]1[S:20][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)[N:21]=1)[CH2:16][CH3:17]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 1615208Propyl-2-thiourea

Produkt 1

HCID 23082954N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7914Diisopropyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (5.34 g), N-propylthiourea (2.60 g) and ethanol (50 mL) was stirred for 1 hr while heating under reflux. The reaction mixture was cooled and diluted with isopropyl ether. The precipitated solid was collected by filtration, washed with isopropyl ether and dried to give the title compound (5.11 g, yield 70%) as colorless crystals.

Aufarbeitung

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with isopropyl ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-be129a25c75a4a96a67dd0170d5191f1
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960369B2

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