Imidazole → ethyl 2-(1H-imidazol-1-yl)acetate

HRID 242258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242258
[Na].[NH:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.Br[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(O)C>[CH2:12]([O:11][C:9](=[O:10])[CH2:8][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1)[CH3:13]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 7748Ethyl bromoacetateHCID 5360545Sodium

Produkt 1

HCID 3798501ethyl 2-(1H-imidazol-1-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

118.2 g (5.1 mol) sodium are slowly added to 2.5 liters ethanol. 350.0 g (5.1 mol) imidazole are then added and 570 ml (858.6 g, 5.1 mol) ethyl bromoacetate are added dropwise at an internal temperature of 20-25° C. The mixture is stirred at RT for 24 h. The solid which has precipitated out is filtered off, the ethanol is removed in vacuo and the mixture is filtered again. The residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate).

Aufarbeitung

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. customthe ethanol is removed in vacuo
  4. filtrationthe mixture is filtered again
  5. customThe residue is purified by column chromatography over silica gel (mobile phase: ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-18f996ed93524ea7b83dd37ad0a09225
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653111B2

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