Anthranilic Acid → 2-(2-Methoxy-4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)-3-methylquinazolin-4(3H)-one

HRID 2422586

Reaktionsgleichung

Reaktionsgleichung von HRID 2422586
[C:1]([OH:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[CH3:11][NH2:12].[OH:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[C:16]([O:22][CH3:23])[CH:15]=1.Cl[CH2:25][CH2:26][CH2:27]Br.[CH3:29][C@H:30]1[CH2:35][CH2:34][CH2:33][NH:32][CH2:31]1.C([O-])(=O)[C@@H](C1C=CC=CC=1)O>>[CH3:23][O:22][C:16]1[CH:15]=[C:14]([O:13][CH2:25][CH2:26][CH2:27][N:32]2[CH2:33][CH2:34][CH2:35][C@H:30]([CH3:29])[CH2:31]2)[CH:21]=[CH:20][C:17]=1[C:18]1[N:12]([CH3:11])[C:1](=[O:10])[C:2]2[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:4]=1

Komponenten

7

Edukt 6

HCID 227Anthranilic AcidHCID 6329MethylamineHCID 80061-Bromo-3-chloropropaneHCID 5195414-Hydroxy-2-MethoxybenzaldehydeHCID 641100(S)-3-MethylpiperidineHCID 5460269(R)-Mandelate

Produkt 1

HCID 115246202-(2-Methoxy-4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}phenyl)-3-methylquinazolin-4(3H)-one

Versuchsvorschrift

The entitled compound was obtained according to the method of Example 1 but starting from anthranilic acid, methylamine, 4-hydroxy-2-methoxybenzaldehyde, 1-chloro-3-bromopropane and (3S)-3-methylpiperidine.(R)-mandelate.

Aufarbeitung

  1. customThe entitled compound was obtained

Quellen und Nachweise

ORD-Eintrag
ord-d9c3f9ea6a474542981abb432eb5cb2e
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960394B2

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