Methylamine → 2-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

HRID 2422621

Reaktionsgleichung

Reaktionsgleichung von HRID 2422621
[NH2:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][C:5]([O:11][CH3:12])=[N:4][CH:3]=1.[CH3:13][NH2:14].[CH:15]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([N:20]2[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:34]=[CH:33][C:30]([C:31]4[N:14]([CH3:13])[C:8](=[O:10])[C:7]5[CH:6]=[C:5]([O:11][CH3:12])[N:4]=[CH:3][C:2]=5[N:1]=4)=[CH:29][CH:28]=3)[CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Komponenten

4

Edukt 3

HCID 6329MethylamineHCID 27625075-Amino-2-methoxypyridine-4-carboxylic acidHCID 866244604-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde

Produkt 1

HCID 115393322-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-6-methoxy-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one

Versuchsvorschrift

The entitled compound was obtained according to the method of Example 15 but starting from 5-amino-2-methoxyisonicotinic acid, methylamine and 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde.

Aufarbeitung

  1. customThe entitled compound was obtained

Quellen und Nachweise

ORD-Eintrag
ord-a631bf5edc344b8188a6eb0996cbf6b3
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960394B2

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