3-(Tert-butoxycarbonylamino)-2-methoxyisonicotinic acid → 3-Amino-2-methoxyisonicotinic acid

Beteiligte Stoffe

Reaktionsschritte

3-[(T-butoxycarbonyl)amino]-2-methoxyisonicotinic acid (6.6 g, 24.6 mmol) was dissolved in trifluoroacetic acid (10 mL), and stirred at room temperature for 8 hours. The solvent was evaporated off under reduced pressure, and the resulting milky white solid was washed with water and ethanol to obtain a white solid (2.35 g, 56.8%). The mother liquid was again concentrated, and the resulting residue was washed with acetone and hexane to obtain a pale pink solid (1.3 g, 31.4%).

Herkunft & Nachweise