Trifluoroacetic acid → HCID 67245959, Verbindung

HRID 2422854Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2422854
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][C@@H:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C:24]([O:29][CH3:30])=[N:25][CH:26]=[CH:27][CH:28]=2)=[CH:19][CH:18]=1)[CH3:16])(C)(C)C>ClCCl>[CH3:30][O:29][C:24]1[C:23]([C:20]2[CH:21]=[CH:22][C:17]([C@H:15]([NH2:14])[CH3:16])=[CH:18][CH:19]=2)=[CH:28][CH:27]=[CH:26][N:25]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67244774(R)-{1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}carbamic acid tert-butyl ester

Produkt 1

HCID 67245959HCID 67245959, VerbindungAusbeute 94,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

2M Aqueous sodium carbonate solution (3.25 ml, 6.50 mmol) was added to a mixture of 2-methoxypyridine-3-boronic acid (994 mg, 6.50 mmol), (R)-[1-(4-bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester (650 mg, 2.16 mmol) and tetrakis(triphenylphosphine)palladium (0) (125 mg, 0.108 mmol) in 1,2 dimethoxyethane (27 ml). The mixture was heated at 95° C. for 16 h under nitrogen atmosphere. The solvent was evaporated and the residue partitioned between ethyl acetate and water. The organic phase was washed twice with brine, dried over anhydrous magnesium sulfate and the solvent evaporated. The resulting gum was chromatographed over silica gel eluting with heptane/dichloromethane and the solvent evaporated to give (R)-{1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester (593 mg, 1.71 mmol, 83.5%) as a crystalline solid. Trifluoroacetic acid (6.45 ml, 86.8 mmol) was added dropwise to a solution of (R)-{1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethyl}carbamic acid tert-butyl ester (645 mg, 1.97 mmol) in dichloromethane (6.45 ml) under a nitrogen atmosphere at 0° C. After stirring for 1 h at 0° C. the solvent was evaporated. Methanol (20 ml) was added and the mixture added to a Strata™ 5 g/20 ml SCX column. The intermediate amine was eluted with 2M ammonia in methanol. The solvent was evaporated to give (R)-1-[4-(2-methoxy-pyridin-3-yl)-phenyl]-ethylamine as a gum (425 mg, 1.86 mmol, 94.6%). The title compound was then prepared in a similar manner to (R)-2,5-dimethyl-furan-3-sulfonic acid [1-(5′-fluoro-2′-methoxy-biphenyl-4-yl)-ethyl]-amide (Example 10) using 4-bromo-3-thiophenesulfonyl chloride and 1-[4-(2-Methoxy-pyridin-3-yl)-phenyl]-ethylamine. Title compound: 1H NMR (400 MHz, CDCl3): δ 8.17 (d, 1H), 7.56 (d, 1H), 7.41, 7.20 (a/b, 4H), 7.38 (m, 1H), 6.99-6.92 (m, 2H), 5.27 (d, 1H), 4.60 (m, 1H), 3.97 (s, 3H), 1.54 (d, 3H) ppm; MS (ESI) m/z: 453 [M+H]+.

Aufarbeitung

  1. customwas evaporated
  2. additionMethanol (20 ml) was added
  3. additionthe mixture added to a Strata™ 5 g/20 ml SCX column
  4. washThe intermediate amine was eluted with 2M ammonia in methanol
  5. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-395ad780ff6f4616ae1ec8c56645da6e
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960365B2

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